Baldelli, E., Calvert, V., Hodge, A., VanMeter, A., Petricoin, E.F., and Pierobon, M. (2017). Reverse Phase Protein Microarrays. Methods Mol. Biol. Clifton NJ 1606, 149–169.

Bell, T.M., Espina, V., Senina, S., Woodson, C., Brahms, A., Carey, B., Lin, S.-C., Lundberg, L., Pinkham, C., Baer, A., et al. (2017). Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis. Antiviral Res. 143, 162–175.

Gordon, M.A., D’Amato, N.C., Gu, H., Babbs, B., Wulfkuhle, J., Petricoin, E.F., Gallagher, I., Dong, T., Torkko, K., Liu, B., et al. (2017). Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer. Mol. Cancer Ther. 16, 1389–1400.

Ludovini, V., Chiari, R., Tomassoni, L., Antonini, C., Baldelli, E., Baglivo, S., Sigillino, A., Tofanetti, F.R., Bellezza, G., Hodge, K.A., et al. (2017). Reverse phase protein array (RPPA) combined with computational analysis to unravel relevant prognostic factors in non- small cell lung cancer (NSCLC): a pilot study. Oncotarget.

Mehta, H., Tidwell, L., and Liotta, L.A. (2017). Inventions and Patents: A Practical Tutorial. Methods Mol. Biol. Clifton NJ 1606, 379–397.

Mueller, C., Harpole, M.G., and Espina, V. (2017). One-Step Preservation and Decalcification of Bony Tissue for Molecular Profiling. Methods Mol. Biol. Clifton NJ 1606, 85–102.

Pierobon, M., Ramos, C., Wong, S., Hodge, K.A., Aldrich, J., Byron, S., Anthony, S.P., Robert, N.J., Northfelt, D.W., Jahanzeb, M., et al. (2017). Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res.

Romano, A., Giallongo, C., La Cava, P., Parrinello, N.L., Chiechi, A., Vetro, C., Tibullo, D., Di Raimondo, F., Liotta, L.A., Espina, V., et al. (2017). Proteomic Analysis Reveals Autophagy as Pro-Survival Pathway Elicited by Long-Term Exposure with 5-Azacitidine in High-Risk Myelodysplasia. Front. Pharmacol. 8, 204.

Sereni, M.I., Baldelli, E., Gambara, G., Ravaggi, A., Hodge, K.A., Alberts, D.S., Guillen-Rodriguez, J.M., Dong, T., Memo, M., Odicino, F., et al. (2017). Kinase-driven metabolic signalling as a predictor of response to carboplatin-paclitaxel adjuvant treatment in advanced ovarian cancers. Br. J. Cancer.

Simbulan-Rosenthal, C.M., Dakshanamurthy, S., Gaur, A., Chen, Y.-S., Fang, H.-B., Abdussamad, M., Zhou, H., Zapas, J., Calvert, V., Petricoin, E.F., et al. (2017). The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma. Oncotarget 8, 12576–12595.

Spreafico, F., Bongarzone, I., Pizzamiglio, S., Magni, R., Taverna, E., De Bortoli, M., Ciniselli, C.M., Barzanò, E., Biassoni, V., Luchini, A., et al. (2017). Proteomic analysis of cerebrospinal fluid from children with central nervous system tumors identifies candidate proteins relating to tumor metastatic spread. Oncotarget 8, 46177–46190.

Staunton, L., Tonry, C., Lis, R., Espina, V., Liotta, L., Inzitari, R., Bowden, M., Fabre, A., O’Leary, J., Finn, S.P., et al. (2017). Pathology-Driven Comprehensive Proteomic Profiling of the Prostate Cancer Tumor Microenvironment. Mol. Cancer Res. MCR 15, 281–293.

Varghese, R.S., Zuo, Y., Zhao, Y., Zhang, Y.-W., Jablonski, S.A., Pierobon, M., Petricoin, E.F., Ressom, H.W., and Weiner, L.M. (2017). Protein network construction using reverse phase protein array data. Methods San Diego Calif.

Wulfkuhle, J.D., Spira, A., Edmiston, K.H., and Petricoin, E.F. (2017). Innovations in Clinical Trial Design in the Era of Molecular Profiling. Methods Mol. Biol. Clifton NJ 1606, 19–36.

Yeon, S., Bell, F., Shultz, M., Lawrence, G., Harpole, M., and Espina, V. (2017). Dual-Color, Multiplex Analysis of Protein Microarrays for Precision Medicine. Methods Mol. Biol. Clifton NJ 1550, 149–170.

Zhang, X., Liu, P., Zhang, C., Chiewchengchol, D., Zhao, F., Yu, H., Li, J., Kambara, H., Luo, K.Y., Venkataraman, A., et al. (2017a). Positive Regulation of Interleukin-1β Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation. Cell Rep. 20, 224–235.

Zhang, Y., Cruickshanks, N., Yuan, F., Wang, B., Pahuski, M., Wulfkuhle, J., Gallagher, I., Koeppel, A.F., Hatef, S., Papanicolas, C., et al. (2017b). Targetable T-type Calcium Channels Drive Glioblastoma. Cancer Res. 77, 3479–3490.

Zhou, W., Liotta, L.A., and Petricoin, E.F. (2017a). The Warburg Effect and Mass Spectrometry-based Proteomic Analysis. Cancer Genomics Proteomics 14, 211–218.

Zhou, W., Petricoin, E.F., and Longo, C. (2017b). Mass Spectrometry-Based Biomarker Discovery. Methods Mol. Biol. Clifton NJ 1606, 297–311.


Ayyadevara, S., Balasubramaniam, M., Parcon, P.A., Barger, S.W., Griffin, W.S.T., Alla, R., Tackett, A.J., Mackintosh, S.G., Petricoin, E., Zhou, W., et al. (2016). Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer’s hippocampus from normal controls. Aging Cell 15, 924–939.

Castro-Sesquen, Y.E., Gilman, R.H., Mejia, C., Clark, D.E., Choi, J., Reimer-McAtee, M.J., Castro, R., Valencia-Ayala, E., Flores, J., Bowman, N., et al. (2016). Use of a Chagas Urine Nanoparticle Test (Chunap) to Correlate with Parasitemia Levels in T. cruzi/HIV Co-infected Patients. PLoS Negl. Trop. Dis. 10, e0004407.

Ceglia, I., Dueck, A.C., Masiello, F., Martelli, F., He, W., Federici, G., Petricoin, E.F., Zeuner, A., Iancu-Rubin, C., Weinberg, R., et al. (2016). Preclinical rationale for TGF-β inhibition as a therapeutic target for the treatment of myelofibrosis. Exp. Hematol. 44, 1138–1155.e4.

Conti, A., Fredolini, C., Tamburro, D., Magagnoli, G., Zhou, W., Liotta, L.A., Picci, P., Luchini, A., and Benassi, M.S. (2016). Identification of novel candidate circulating biomarkers for malignant soft tissue sarcomas: Correlation with metastatic progression. Proteomics 16, 689–697.

Douglas, D.B., Boone, J.M., Petricoin, E., Liotta, L., and Wilson, E. (2016a). Augmented Reality Imaging System: 3D Viewing of a Breast Cancer. J. Nat. Sci. 2.

Douglas, D.B., Petricoin, E.F., Liotta, L., and Wilson, E. (2016b). D3D augmented reality imaging system: proof of concept in mammography. Med. Devices Auckl. NZ 9, 277–283.

Espina, V., Williams, J.P., and Liotta, L.A. (2016). Treatment and Long-Term Risks for Patients With a Diagnosis of Ductal Carcinoma In Situ. JAMA Oncol. 2, 395.

Harpole, M., Davis, J., and Espina, V. (2016). Current state of the art for enhancing urine biomarker discovery. Expert Rev. Proteomics 13, 609–626.

Janda, J., Burkett, N.B., Blohm-Mangone, K., Huang, V., Curiel-Lewandrowski, C., Alberts, D.S., Petricoin, E.F., Calvert, V.S., Einspahr, J., Dong, Z., et al. (2016). Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochem. Photobiol. 92, 816–825.

Jeong, J., VanHouten, J.N., Dann, P., Kim, W., Sullivan, C., Yu, H., Liotta, L., Espina, V., Stern, D.F., Friedman, P.A., et al. (2016). PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc. Natl. Acad. Sci. U. S. A. 113, E282-290.

Liotta, L.A. (2016). Adhere, Degrade, and Move: The Three-Step Model of Invasion. Cancer Res. 76, 3115–3117.

Parasido, E.M., Silvestri, A., Canzonieri, V., Belluco, C., Diodoro, M.G., Milione, M., Melotti, F., De Maria, R., Liotta, L., Petricoin, E.F., et al. (2016). Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine. Oncotarget.

Pin, E., Stratton, S., Belluco, C., Liotta, L., Nagle, R., Hodge, K.A., Deng, J., Dong, T., Baldelli, E., Petricoin, E., et al. (2016). A pilot study exploring the molecular architecture of the tumor microenvironment in human prostate cancer using laser capture microdissection and reverse phase protein microarray. Mol. Oncol. 10, 1585–1594.

Popova, T.G., Teunis, A., Espina, V., Liotta, L.A., and Popov, S.G. (2016). Chemokine-Releasing Microparticles Improve Bacterial Clearance and Survival of Anthrax Spore-Challenged Mice. PloS One 11, e0163163.

Hayes, T.K., Neel, N.F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K.L., Pierobon, M., Marayati, R., Kher, S., George, S.D., Xu, M., Wang-Gillam, A., Samatar, A.A., Maitra, A., Wennerberg, K., Petricoin, E.F., Yin, H.H., Nelkin, B., Cox, A.D., Yeh, J.J., Der, C.J., 2016. Long-term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Cancer Cell.


Alem, F., Yao, K., Lane, D., Calvert, V., Petricoin, E.F., Kramer, L., Hale, M.L., Bavari, S., Panchal, R.G., Hakami, R.M., 2015. Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways. Front. Microbiol. 6, 50.

Baldelli, E., Bellezza, G., Haura, E.B., Crinó, L., Cress, W.D., Deng, J., Ludovini, V., Sidoni, A., Schabath, M.B., Puma, F., Vannucci, J., Siggillino, A., Liotta, L.A., Petricoin, E.F., Pierobon, M., 2015. Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors. Oncotarget 6, 32368–32379.

Baldelli, E., Haura, E.B., Crinò, L., Cress, D.W., Ludovini, V., Schabath, M.B., Liotta, L.A., Petricoin, E.F., Pierobon, M., 2015. Impact of upfront cellular enrichment by laser capture microdissection on protein and phosphoprotein drug target signaling activation measurements in human lung cancer: Implications for personalized medicine. Proteomics Clin. Appl. 9, 928–937.

Bishop, B.M., Juba, M.L., Devine, M.C., Barksdale, S.M., Rodriguez, C.A., Chung, M.C., Russo, P.S., Vliet, K.A., Schnur, J.M., van Hoek, M.L., 2015. Bioprospecting the American alligator (Alligator mississippiensis) host defense peptidome. PloS One 10, e0117394.

Marmiroli, S., Fabbro, D., Miyata, Y., Pierobon, M., Ruzzene, M., 2015. Phosphorylation, Signaling, and Cancer: Targets and Targeting. BioMed Res. Int. 2015, 601543.

Corcoran, R.B., Atreya, C.E., Falchook, G.S., Kwak, E.L., Ryan, D.P., Bendell, J.C., Hamid, O., Messersmith, W.A., Daud, A., Kurzrock, R., Pierobon, M., Sun, P., Cunningham, E., Little, S., Orford, K., Motwani, M., Bai, Y., Patel, K., Venook, A.P., Kopetz, S., 2015. Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 33, 4023–4031.

Consonni, D., Pierobon, M., Gail, M.H., Rubagotti, M., Rotunno, M., Goldstein, A., Goldin, L., Lubin, J., Wacholder, S., Caporaso, N.E., Bertazzi, P.A., Tucker, M.A., Pesatori, A.C., Landi, M.T., 2015. Lung cancer prognosis before and after recurrence in a population-based setting. J. Natl. Cancer Inst. 107, djv059.

Boone, B.A., Bahary, N., Zureikat, A.H., Moser, A.J., Normolle, D.P., Wu, W.-C., Singhi, A.D., Bao, P., Bartlett, D.L., Liotta, L.A., Espina, V., Loughran, P., Lotze, M.T., Zeh, H.J., 2015. Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma. Ann. Surg. Oncol. 22, 4402–4410.

Blanco, F.F., Jimbo, M., Wulfkuhle, J., Gallagher, I., Deng, J., Enyenihi, L., Meisner-Kober, N., Londin, E., Rigoutsos, I., Sawicki, J.A., Risbud, M.V., Witkiewicz, A.K., McCue, P.A., Jiang, W., Rui, H., Yeo, C.J., Petricoin, E., Winter, J.M., Brody, J.R., 2015. The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells. Oncogene.

Bowie, M., Pilie, P., Wulfkuhle, J., Lem, S., Hoffman, A., Desai, S., Petricoin, E., Carter, A., Ambrose, A., Seewaldt, V., Yu, D., Ibarra Drendall, C., 2015. Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer. World J. Clin. Oncol. 6, 299–311.

Budd, W.T., Seashols-Williams, S.J., Clark, G.C., Weaver, D., Calvert, V., Petricoin, E., Dragoescu, E.A., O’Hanlon, K., Zehner, Z.E., 2015. Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis. PloS One 10, e0142373.

Capello, M., Ferri-Borgogno, S., Riganti, C., Chattaragada, M.S., Principe, M., Roux, C., Zhou, W., Petricoin, E.F., Cappello, P., Novelli, F., 2015. Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest. Oncotarget.

Conti, A., Fredolini, C., Tamburro, D., Magagnoli, G., Zhou, W., Liotta, L.A., Picci, P., Luchini, A., Benassi, M.S., 2015. Identification of novel candidate circulating biomarkers for malignant soft tissue sarcomas: Correlation with metastatic progression. Proteomics.

Dailing, A., Luchini, A., Liotta, L., 2015. Unlocking the secrets to protein-protein interface drug targets using structural mass spectrometry techniques. Expert Rev. Proteomics 12, 457–467.

Guendel, I., Iordanskiy, S., Sampey, G.C., Van Duyne, R., Calvert, V., Petricoin, E., Saifuddin, M., Kehn-Hall, K., Kashanchi, F., 2015. Role of Bruton’s tyrosine kinase inhibitors in HIV-1-infected cells. J. Neurovirol. 21, 257–275.

Juba, M.L., Russo, P.S., Devine, M., Barksdale, S., Rodriguez, C., Vliet, K.A., Schnur, J.M., van Hoek, M.L., Bishop, B.M., 2015. Large Scale Discovery and De Novo-Assisted Sequencing of Cationic Antimicrobial Peptides (CAMPs) by Microparticle Capture and Electron-Transfer Dissociation (ETD) Mass Spectrometry. J. Proteome Res. 14, 4282–4295.

LeBlanc, F.R., Liu, X., Hengst, J., Fox, T., Calvert, V., Petricoin, E.F., Yun, J., Feith, D.J., Loughran, T.P., 2015. Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. Cancer Biol. Ther. 0.

Magni, R., Espina, B.H., Shah, K., Lepene, B., Mayuga, C., Douglas, T.A., Espina, V., Rucker, S., Dunlap, R., Petricoin, E.F.I., Kilavos, M.F., Poretz, D.M., Irwin, G.R., Shor, S.M., Liotta, L.A., Luchini, A., 2015. Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis. J. Transl. Med. 13, 346.

Pierobon, M., Wulfkuhle, J., Liotta, L., Petricoin, E., 2015. Application of molecular technologies for phosphoproteomic analysis of clinical samples. Oncogene 34, 805–814.

Popova, T.G., Teunis, A., Magni, R., Luchini, A., Espina, V., Liotta, L.A., Popov, S.G., 2015. Chemokine-Releasing Nanoparticles for Manipulation of Lymph Node Microenvironment. Nanomater. Basel Switz. 5, 298–320.

Popova, T.G., Teunis, A., Vaseghi, H., Zhou, W., Espina, V., Liotta, L.A., Popov, S.G., 2015. Nitric oxide as a regulator of B. anthracis pathogenicity. Front. Microbiol. 6, 921.

Sereni, M.I., Baldelli, E., Gambara, G., Deng, J., Zanotti, L., Bandiera, E., Bignotti, E., Ragnoli, M., Tognon, G., Ravaggi, A., Meani, F., Memo, M., Angioli, R., Liotta, L.A., Pecorelli, S.L., Petricoin, E., Pierobon, M., 2015. Functional characterization of epithelial ovarian cancer histotypes by drug target based protein signaling activation mapping: implications for personalized cancer therapy. Proteomics 15, 365–373.

Zhou, W., Liotta, L.A., Petricoin, E.F., 2015. Cancer metabolism and mass spectrometry-based proteomics. Cancer Lett. 356, 176–183.


Akbani, R., Becker, K.-F., Carragher, N., Goldstein, T., de Koning, L., Korf, U., Liotta, L., Mills, G.B., Nishizuka, S.S., Pawlak, M., Petricoin, E.F., Pollard, H.B., Serrels, B., Zhu, J., 2014. Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society. Mol. Cell. Proteomics MCP 13, 1625–1643.

Magni, R., Espina, B.H., Liotta, L.A., Luchini, A., Espina, V., 2014. Hydrogel nanoparticle harvesting of plasma or urine for detecting low abundance proteins. J. Vis. Exp. JoVE e51789.

Narayanan, A., Amaya, M., Voss, K., Chung, M., Benedict, A., Sampey, G., Kehn-Hall, K., Luchini, A., Liotta, L., Bailey, C., Kumar, A., Bavari, S., Hakami, R.M., Kashanchi, F., 2014. Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells. Virology 449, 270–286.

Salhia, B., Kiefer, J., Ross, J.T.D., Metapally, R., Martinez, R.A., Johnson, K.N., DiPerna, D.M., Paquette, K.M., Jung, S., Nasser, S., Wallstrom, G., Tembe, W., Baker, A., Carpten, J., Resau, J., Ryken, T., Sibenaller, Z., Petricoin, E.F., Liotta, L.A., Ramanathan, R.K., Berens, M.E., Tran, N.L., 2014. Integrated genomic and epigenomic analysis of breast cancer brain metastasis. PloS One 9, e85448.

Shafagati, N., Patanarut, A., Luchini, A., Lundberg, L., Bailey, C., Petricoin, E., Liotta, L., Narayanan, A., Lepene, B., Kehn-Hall, K., 2014. The use of Nanotrap particles for biodefense and emerging infectious disease diagnostics. Pathog. Dis. 71, 164–176.

VanMeter-Adams, A., Frankenfeld, C.L., Bases, J., Espina, V., Liotta, L.A., 2014. Students who demonstrate strong talent and interest in STEM are initially attracted to STEM through extracurricular experiences. CBE Life Sci. Educ. 13, 687–697.

Popova, T.G., Espina, V., Zhou, W., Mueller, C., Liotta, L., Popov, S.G., 2014. Whole proteome analysis of mouse lymph nodes in cutaneous anthrax. PloS One 9, e110873.

Pierobon, M., Silvestri, A., Spira, A., Reeder, A., Pin, E., Banks, S., Parasido, E., Edmiston, K., Liotta, L., Petricoin, E., 2014. Pilot phase I/II personalized therapy trial for metastatic colorectal cancer: evaluating the feasibility of protein pathway activation mapping for stratifying patients to therapy with imatinib and panitumumab. J. Proteome Res. 13, 2846–2855.

Luchini, A., Espina, V., Liotta, L.A., 2014. Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces. Nat. Commun. 5, 4413.

Jaworski, E., Saifuddin, M., Sampey, G., Shafagati, N., Van Duyne, R., Iordanskiy, S., Kehn-Hall, K., Liotta, L., Petricoin, E., Young, M., Lepene, B., Kashanchi, F., 2014. The use of Nanotrap particles technology in capturing HIV-1 virions and viral proteins from infected cells. PloS One 9, e96778.

Mueller, C., deCarvalho, A.C., Mikkelsen, T., Lehman, N.L., Calvert, V., Espina, V., Liotta, L.A., Petricoin, E.F., 2014. Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations. Cancer Res. 74, 818–828.

Liotta, L.A., Petricoin, E.F., 2014. Multiplex proteomic analysis of cells in fine needle aspiration samples: how soon can we expect to individualize therapy by comparing pre- and posttreatment biopsies? Clin. Chem. 60, 1143–1145. doi:10.1373/clinchem.2014.222828

Amaya, M., Voss, K., Sampey, G., Senina, S., de la Fuente, C., Mueller, C., Calvert, V., Kehn-Hall, K., Carpenter, C., Kashanchi, F., Bailey, C., Mogelsvang, S., Petricoin, E., Narayanan, A., 2014. The role of IKKβ in Venezuelan equine encephalitis virus infection. PloS One 9, e86745.

Bertacchini, J., Guida, M., Accordi, B., Mediani, L., Martelli, A.M., Barozzi, P., Petricoin, E., Liotta, L., Milani, G., Giordan, M., Luppi, M., Forghieri, F., De Pol, A., Cocco, L., Basso, G., Marmiroli, S., 2014. Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis. Leukemia 28, 2197–2205.

Castro-Sesquen, Y.E., Gilman, R.H., Galdos-Cardenas, G., Ferrufino, L., Sánchez, G., Valencia Ayala, E., Liotta, L., Bern, C., Luchini, A., Working Group on Chagas Disease in Bolivia and Peru, 2014. Use of a novel chagas urine nanoparticle test (chunap) for diagnosis of congenital chagas disease. PLoS Negl. Trop. Dis. 8, e3211.

Jameson, G.S., Petricoin, E.F., Sachdev, J., Liotta, L.A., Loesch, D.M., Anthony, S.P., Chadha, M.K., Wulfkuhle, J.D., Gallagher, R.I., Reeder, K.A., Pierobon, M., Fulk, M.R., Cantafio, N.A., Dunetz, B., Mikrut, W.D., Von Hoff, D.D., Robert, N.J., 2014. A pilot study utilizing multi-omic molecular profiling to find potential targets and select individualized treatments for patients with previously treated metastatic breast cancer. Breast Cancer Res. Treat. 147, 579–588.

Colarossi, L., Memeo, L., Colarossi, C., Aiello, E., Iuppa, A., Espina, V., Liotta, L., Mueller, C., 2014. Inhibition of histone deacetylase 4 increases cytotoxicity of docetaxel in gastric cancer cells. Proteomics Clin. Appl. 8, 924–931.

Conti, A., Espina, V., Chiechi, A., Magagnoli, G., Novello, C., Pazzaglia, L., Quattrini, I., Picci, P., Liotta, L.A., Benassi, M.S., 2014. Mapping protein signal pathway interaction in sarcoma bone metastasis: linkage between rank, metalloproteinases turnover and growth factor signaling pathways. Clin. Exp. Metastasis 31, 15–24.

Espina, V., Edmiston, K.H., Liotta, L.A., 2014. Non-enzymatic, serum-free tissue culture of pre-invasive breast lesions for spontaneous generation of mammospheres. J. Vis. Exp. JoVE e51926.

Cremona, M., Espina, V., Caccia, D., Veneroni, S., Colecchia, M., Pierobon, M., Deng, J., Mueller, C., Procopio, G., Lanzi, C., Daidone, M.G., Cho, W.C.S., Petricoin, E.F., Liotta, L., Bongarzone, I., 2014. Stratification of clear cell renal cell carcinoma by signaling pathway analysis. Expert Rev. Proteomics 11, 237–249.


Golubeva Y, Salcedo R, Mueller C, Liotta LA, Espina V. Laser capture microdissection for protein and NanoString RNA analysis. Methods Mol. Biol. 2013;931:213–257.

Page S, Birerdinc A, Estep M, Stepanova M, Afendy A, Petricoin E, Younossi Z, Chandhoke V, Baranova A. Knowledge-Based Identification of Soluble Biomarkers: Hepatic Fibrosis in NAFLD as an Example. PLoS ONE 2013;8(2):e56009.

Pierobon M, Frankenfeld CL. Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Res. Treat. 2013 Jan;137(1):307–314.

Xu L, Elkahloun AG, Candotti F, Grajkowski A, Beaucage SL, Petricoin EF, et al. A novel function of RNAs arising from the long terminal repeat of human endogenous retrovirus 9 in cell cycle arrest. J Virol. 2013 Jan;87(1):25–36.

Zhang Y, Farenholtz K, Yang Y, Guessous F, Dipierro CG, Calvert V, Deng J, Schiff D, Xin W, Lee J, Purow BW, Christensen JG, Petricoin EF 3rd, Abounader R. Hepatocyte growth factor sensitizes brain tumors to c-Met kinase inhibition. Clin. Cancer Res. 2013 Feb.

Albanese C, Rodriguez OC, Vanmeter J, Fricke ST, Rood BR, Lee Y, Wang SS, Madhavan S, Gusev Y, Petricoin EF 3rd, Wang Y. Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges. Am. J. Pathol. 2013 Feb;182(2):312–318.

Silvestri A, Calvert V, Belluco C, Lipsky M, De Maria R, Deng J, Colombatti A, De Marchi F, Nitti D, Mammano E, Liotta L, Petricoin E, Pierobon M. Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations. Clin. Exp. Metastasis 2013 Mar;30(3):309–316.

Sereni MI, Pierobon M, Angioli R, Petricoin EF 3rd, Frederick MJ. Reverse phase protein microarrays and their utility in drug development. Methods Mol. Biol. 2013;986:187–214.

Espina V, Wysolmerski J, Edmiston K, Liotta LA. Attacking breast cancer at the preinvasion stage by targeting autophagy. Womens Heal Lond Engl. 2013 Mar;9(2):157–70.

Pin E, Fredolini C, Petricoin EF 3rd. The role of proteomics in prostate cancer research: biomarker discovery and validation. Clin Biochem. 2013 Apr;46(6):524–38.

Zhou W, Capello M, Fredolini C, Racanicchi L, Dugnani E, Piemonti L, et al. Mass spectrometric analysis reveals O-methylation of pyruvate kinase from pancreatic cancer cells. Anal Bioanal Chem. 2013 May;405(14):4937–43.

Chiechi A, Novello C, Magagnoli G, Petricoin EF 3rd, Deng J, Benassi MS, et al. Elevated TNFR1 and serotonin in bone metastasis are correlated with poor survival following bone metastasis diagnosis for both carcinoma and sarcoma primary tumors. Clin Cancer Res Off J Am Assoc Cancer Res. 2013 May 1;19(9):2473–85.

Federici G, Gao X, Slawek J, Arodz T, Shitaye A, Wulfkuhle JD, et al. Systems analysis of the NCI-60 cancer cell lines by alignment of protein pathway activation modules with “-OMIC” data fields and therapeutic response signatures. Mol Cancer Res MCR. 2013 Jun;11(6):676–85.

Conti A, Espina V, Chiechi A, Magagnoli G, Novello C, Pazzaglia L, et al. Mapping protein signal pathway interaction in sarcoma bone metastasis: linkage between rank, metalloproteinases turnover and growth factor signaling pathways. Clin Exp Metastasis. 2013 Jul 23;

Biasutto L, Chiechi A, Couch R, Liotta LA, Espina V. Retinal pigment epithelium (RPE) exosomes contain signaling phosphoproteins affected by oxidative stress. Exp Cell Res. 2013 Aug 1;319(13):2113–23.

Wilson B, Liotta LA, Petricoin III E. Dynamic protein pathway activation mapping of adipose-derived stem cell differentiation implicates novel regulators of adipocyte differentiation. Mol Cell Proteomics MCP. 2013 Sep;12(9):2522–35.

Hricik T, Federici G, Zeuner A, Alimena G, Tafuri A, Tirelli V, et al. Transcriptomic and phospho-proteomic analyzes of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera. Am J Hematol. 2013 Sep;88(9):723–9.

Bosch J, Luchini A, Pichini S, Tamburro D, Fredolini C, Liotta L, et al. Analysis of urinary human growth hormone (hGH) using hydrogel nanoparticles and isoform differential immunoassays after short recombinant hGH treatment: Preliminary results. J Pharm Biomed Anal. 2013 Nov;85:194–7.

Zhou W, Liotta LA, Petricoin EF. Cancer metabolism and mass spectrometry-based proteomics. Cancer Lett. 2013 Nov 18;

Zhan Y, Cao B, Qi Y, Liu S, Zhang Q, Zhou W, et al. Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer. Int J Cancer J Int Cancer. 2013 Nov;133(9):2225–33.

Chirullo, B., Sgarbanti, R., Limongi, D., Shytaj, I.L., Alvarez, D., Das, B., Boe, A., DaFonseca, S., Chomont, N., Liotta, L., Petricoin, E.I., Norelli, S., Pelosi, E., Garaci, E., Savarino, A., Palamara, A.T., 2013. A candidate anti-HIV reservoir compound, auranofin, exerts a selective “anti-memory” effect by exploiting the baseline oxidative status of lymphocytes. Cell Death Dis. 4, e944.

Holmes, F.A., Espina, V., Liotta, L.A., Nagarwala, Y.M., Danso, M., McIntyre, K.J., Osborne, C.R.C., Anderson, T., Krekow, L., Blum, J.L., Pippen, J., Florance, A., Mahoney, J., O’Shaughnessy, J.A., 2013. Pathologic complete response after preoperative anti-HER2 therapy correlates with alterations in PTEN, FOXO, phosphorylated Stat5, and autophagy protein signaling. BMC Res. Notes 6, 507.

Xia, W., Petricoin, E.F., Zhao, S., Liu, L., Osada, T., Cheng, Q., Wulfkuhle, J.D., Gwin, W.R., Yang, X., Gallagher, R.I., Bacus, S., Lyerly, H.K., Spector, N.L., 2013. An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models. Breast Cancer Res. BCR 15, R85.


Zabel M, Schrag M, Mueller C, Zhou W, Crofton A, Petersen F, Dickson A, Kirsch WM. Assessing candidate serum biomarkers for Alzheimer’s disease: a longitudinal study. J. Alzheimers Dis. 2012 Jan;30(2):311–321.

Mueller C, Schrag M, Crofton A, Stolte J, Muckenthaler MU, Magaki S, Kirsch W. Altered serum iron and copper homeostasis predicts cognitive decline in mild cognitive impairment. J. Alzheimers Dis. 2012;29(2):341–350.

Liotta LA, Petricoin EF 3rd. Regulatory approval pathways for molecular diagnostic technology. Methods Mol. Biol. 2012;823:409–420.

Espina, V, Liotta LA (Eds.). Molecular Profiling, Methods and Protocols. Methods in Molecular Biology, Vol 823. Humana Press, 2012.

Zhou W, Petricoin EF 3rd, Longo C. Mass spectrometry-based biomarker discovery. Methods Mol. Biol. 2012;823:251–264.

Anagostou A, Liotta LA. Small business development for molecular diagnostics. Methods Mol. Biol. 2012;823:421–437.

Tidwell JL, Liotta LA. Inventions and patents: a practical tutorial. Methods Mol. Biol. 2012;823:391–408.

VanMeter AJ, Camerini S, Polci ML, Tessitore A, Trivedi N, Heiby M, Kamal Y, Hansen J, Zhou W. Serum low-molecular-weight protein fractionation for biomarker discovery. Methods Mol. Biol. 2012;823:237–249.

Espina V, Mueller C. Reduction of preanalytical variability in specimen procurement for molecular profiling. Methods Mol. Biol. 2012;823:49–57.

Gallagher RI, Blakely SR, Liotta LA, Espina V. Laser capture microdissection: Arcturus(XT) infrared capture and UV cutting methods. Methods Mol. Biol. 2012;823:157–178.

Pierobon M, Vanmeter AJ, Moroni N, Galdi F, Petricoin EF 3rd. Reverse-phase protein microarrays. Methods Mol. Biol. 2012;823:215–235.

van Agthoven T, Godinho MFE, Wulfkuhle JD, Petricoin EF 3rd, Dorssers LCJ. Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines [Internet]. International journal of cancer. Journal international du cancer 2012 Feb; Available from:

Einspahr JG, Calvert V, Alberts DS, Curiel-Lewandrowski C, Warneke J, Krouse R, Stratton SP, Liotta L, Longo C, Pellicani G, Prasad A, Sagerman P, Bermudez Y, Deng J, Bowden GT, Petricoin EF 3rd. Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma. Cancer Prev Res (Phila) 2012 Mar;5(3):403–413.

Raiszadeh MM, Ross MM, Russo PS, Schaepper MA, Zhou W, Deng J, Ng D, Dickson A, Dickson C, Strom M, Osorio C, Soeprono T, Wulfkuhle JD, Petricoin EF, Liotta LA, Kirsch WM. Proteomic analysis of eccrine sweat: implications for the discovery of schizophrenia biomarker proteins. J. Proteome Res. 2012 Apr;11(4):2127–2139.

Zuurbier L, Petricoin EF, Vuerhard MJ, Calvert V, Kooi C, Buijs-Gladdines J, Smits WK, Sonneveld E, Veerman AJP, Kamps WA, Horstmann M, Pieters R, Meijerink JPP. The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia [Internet]. Haematologica 2012 Apr; Available from:

Zhou W, Liotta LA, Petricoin EF. The Spectra Count Label-free Quantitation in Cancer Proteomics. Cancer Genomics Proteomics 2012 May;9(3):135–142.

Mammano E, Galdi F, Pierobon M, Tessari E, Deng J, Pucciarelli S, Agostini M, De Marchi F, Canzonieri V, De Paoli A, Belluco C, Liotta L, Petricoin E, Pilati P, Nitti D. Multiplexed Protein Signal Pathway Mapping Identifies Patients With Rectal Cancer That Responds to Neoadjuvant Treatment [Internet]. Clinical colorectal cancer 2012 Jun; Available from:

Zhou W, Capello M, Fredolini C, Racanicchi L, Piemonti L, Liotta LA, Novelli F, Petricoin EF. MS analysis reveals O-methylation of L-lactate dehydrogenase from pancreatic ductal adenocarcinoma cells. Electrophoresis 2012 Jul;33(12):1850–1854.

Ibarra-Drendall C, Troch MM, Barry WT, Broadwater G, Petricoin EF 3rd, Wulfkuhle J, Liotta LA, Lem S, Baker JC Jr, Ford AC, Wilke LG, Zalles C, Kuderer NM, Hoffman AW, Shivraj M, Mehta P, Williams J, Tolbert N, Lee LW, Pilie PG, Yu D, Seewaldt VL. Erratum to: Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways [Internet]. Breast Cancer Res. Treat. 2012 Aug; Available from:

Liotta LA, Petricoin EF 3rd. -omics and cancer biomarkers: link to the biological truth or bear the consequences. Cancer Epidemiol. Biomarkers Prev. 2012 Aug;21(8):1229–1235.

Prakash A, Rezai T, Krastins B, Sarracino D, Athanas M, Russo P, Zhang H, Tian Y, Li Y, Kulasingam V, Drabovich A, Smith CR, Batruch I, Oran PE, Fredolini C, Luchini A, Liotta L, Petricoin E, Diamandis EP, Chan DW, Nelson R, Lopez MF. Interlaboratory reproducibility of selective reaction monitoring assays using multiple upfront analyte enrichment strategies. J. Proteome Res. 2012 Aug;11(8):3986–3995.

Chiechi A, Mueller C, Boehm KM, Romano A, Benassi MS, Picci P, Liotta LA, Espina V. Improved data normalization methods for reverse phase protein microarray analysis of complex biological samples. BioTechniques 2012 Sep;0(0):1–7.

Hartsink-Segers SA, Zwaan CM, Exalto C, Luijendijk MWJ, Calvert VS, Petricoin EF, Evans WE, Reinhardt D, de Haas V, Hedtjärn M, Hansen BR, Koch T, Caron HN, Pieters R, Den Boer ML. Aurora kinases in childhood acute leukemia: the promise of Aurora B as therapeutic target. Leukemia 2012 Sep; Available from:

Godinho MFE, Wulfkuhle JD, Look MP, Sieuwerts AM, Sleijfer S, Foekens JA, Petricoin EF 3rd, Dorssers LCJ, van Agthoven T. BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib. Br. J. Cancer 2012 Sep;107(6):947–955.

Jin Q, Pulipati NR, Zhou W, Staub CM, Liotta LA, Mulder KM. Role of km23-1 in RhoA/actin-based cell migration. Biochem. Biophys. Res. Commun. 2012 Nov;428(3):333–338.

Accordi B, Galla L, Milani G, Curtarello M, Serafin V, Lissandron V, Viola G, Te Kronnie G, De Maria R, Petricoin EF 3rd, Liotta LA, Indraccolo S, Basso G. AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells. Leukemia 2012 Nov;

Zhou W, Liotta LA, Petricoin EF. Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry. Cancer Genomics Proteomics 2012 Nov;9(6):373–381.

Kanojia D, Zhou W, Zhang J, Jie C, Lo P-K, Wang Q, et al. Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice. Proteomics. 2012 Nov;12(22):3407–15.

Zupa A, Improta G, Silvestri A, Pin E, Deng J, Aieta M, Musto P, Nitti D, Mammano E, Liotta L, Belluco C, Wulfkuhle J, Petricoin E 3rd. A pilot characterization of human lung NSCLC by protein pathway activation mapping. J Thorac Oncol 2012 Dec;7(12):1755–1766.

Pin E, Fredolini C, Petricoin EF 3rd. The role of proteomics in prostate cancer research: Biomarker discovery and validation. Clin. Biochem. 2012 Dec;

Wulfkuhle JD, Berg D, Wolff C, Langer R, Tran K, Illi J, Espina V, Pierobon M, Deng J, DeMichele A, Walch A, Bronger H, Becker I, Waldhör C, Höfler H, Esserman L, Liotta LA, Becker K-F, Petricoin EF 3rd. Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping. Clin. Cancer Res. 2012 Dec;18(23):6426–6435.

Luchini A, Tamburro D, Magni R, Fredolini C, Espina V, Bosch J, et al. Application of Analyte Harvesting Nanoparticle Technology to the Measurement of Urinary HGH in Healthy Individuals. J Sports Med Doping Stud. 2012;2(6).


Moridani MY, Araujo RP, Johnson CH and Lindon JC. The -Omics in Drug Development. Pharmacokinetics in Drug Development 2011, 145-173.

Pierobon M, Belluco C, Liotta LA, Petricoin EF 3rd. Reverse phase protein microarrays for clinical applications. Methods Mol. Biol. 2011;785:3–12.

Espina V, Mueller C, Liotta LA. Phosphoprotein stability in clinical tissue and its relevance for reverse phase protein microarray technology. Methods Mol. Biol. 2011;785:23–43.

Gallagher RI, Silvestri A, Petricoin EF 3rd, Liotta LA, Espina V. Reverse phase protein microarrays: fluorometric and colorimetric detection. Methods Mol. Biol 2011;723:275–301.

Longo C, Gambara G, Espina V, Luchini A, Bishop B, Patanarut AS, Petricoin EF 3rd, Beretti F, Ferrari B, Garaci E, De Pol A, Pellacani G, Liotta LA. A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum. Exp. Dermatol 2011 Jan;20(1):29-34.

Federici G, Espina V, Liotta L, Edmiston KH. Breast cancer stem cells: a new target for therapy. Oncology (Williston Park, N.Y.) 2011 Jan;25(1):25-28, 30.

Tomaino B, Cappello P, Capello M, Fredolini C, Sperduti I, Migliorini P, Salacone P, Novarino A, Giacobino A, Ciuffreda L, Alessio M, Nisticò P, Scarpa A, Pederzoli P, Zhou W, Petricoin Iii EF, Liotta LA, Giovarelli M, Milella M, Novelli F. Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer. J. Proteome Res 2011 Jan;10(1):105-112.

Georgitsi M, Viennas E, Antoniou DI, Gkantouna V, van Baal S, Petricoin EF 3rd, Poulas K, Tzimas G, Patrinos GP. FINDbase: a worldwide database for genetic variation allele frequencies updated. Nucleic Acids Res 2011 Jan;39(Database issue):D926-932.

Matei D, Sill MW, Lankes HA, DeGeest K, Bristow RE, Mutch D, Yamada SD, Cohn D, Calvert V, Farley J, Petricoin EF, Birrer MJ. Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial. J. Clin. Oncol 2011 Jan;29(1):69-75.

Espina V, Liotta LA. What is the malignant nature of human ductal carcinoma in situ? Nat. Rev. Cancer 2011 Jan;11(1):68-75.

Douglas TA, Tamburro D, Fredolini C, Espina BH, Lepene BS, Ilag L, Espina V, Petricoin EF 3rd, Liotta LA, Luchini A. The use of hydrogel microparticles to sequester and concentrate bacterial antigens in a urine test for Lyme disease. Biomaterials 2011 Feb;32(4):1157-1166.

Frederick MJ, VanMeter AJ, Gadhikar MA, Henderson YC, Yao H, Pickering CC, Williams MD, El-Naggar AK, Sandulache V, Tarco E, Myers JN, Clayman GL, Liotta LA, Petricoin EF 3rd, Calvert VS, Fodale V, Wang J, Weber RS. Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. Am. J. Pathol 2011 Feb;178(2):548-571.

Younossi ZM, Limongi D, Stepanova M, Pierobon M, Afendy A, Mehta R, Baranova A, Liotta L, Petricoin E. Protein pathway activation associated with sustained virologic response in patients with chronic hepatitis C treated with pegylated interferon (PEG-IFN) and ribavirin (RBV). J. Proteome Res 2011 Feb;10(2):774-779.

Maraldi T, Bertacchini J, Benincasa M, Guida M, De Pol A, Liotta LA, Petricoin E, Cocco L, Marmiroli S. Reverse-phase protein microarrays (RPPA) as a diagnostic and therapeutic guide in multidrug resistant leukemia. Int. J. Oncol 2011 Feb;38(2):427-435.

Pilie PG, Ibarra-Drendall C, Troch MM, Broadwater G, Barry WT, Petricoin EF, Wulfkuhle JD, Liotta LA, Lem S, Baker JC, Stouder A, Ford AC, Wilke LG, Zalles CM, Mehta P, Williams J, Shivraj M, Su Z, Geradts J, Yu D, Seewaldt VL. Protein Microarray Analysis of Mammary Epithelial Cells from Obese and Nonobese Women at High Risk for Breast Cancer: Feasibility Data. Cancer Epidemiology Biomarkers & Prevention 2011 Mar;20(3):476 -482.

Napoletani D, Signore M, Sauer T, Liotta L, Petricoin E. Homologous control of protein signaling networks. J Theor Biol 2011 Mar;279(1):29-43.

Pierson T, Matrakas D, Taylor YU, Manyam G, Morozov VN, Zhou W, van Hoek ML. Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine. J. Proteome Res 2011 Mar;10(3):954-967.

Manes NP, Dong L, Zhou W, Du X, Reghu N, Kool AC, Choi D, Bailey CL, Petricoin EF 3rd, Liotta LA, Popov SG. Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol. Cell Proteomics 2011 Mar;10(3):M110.000927.

Anderson T, Wulfkuhle J, Petricoin E, Winslow RL. High resolution mapping of the cardiac transmural proteome using reverse phase protein microarrays [Internet]. Mol Cell Proteomics 2011 Apr; Available from:

Fodale V, Pierobon M, Liotta L, Petricoin E. Mechanism of cell adaptation: when and how do cancer cells develop chemoresistance? Cancer J 2011 Apr;17(2):89-95.

Zhou W, Capello M, Fredolini C, Piemonti L, Liotta LA, Novelli F, Petricoin EF. Proteomic analysis of pancreatic ductal adenocarcinoma cells reveals metabolic alterations. J. Proteome Res 2011 Apr;10(4):1944–1952.

Gallagher RI, Silvestri A, Petricoin EF 3rd, Liotta LA, Espina V. Reverse phase protein microarrays: fluorometric and colorimetric detection. Methods Mol. Biol 2011;723:275-301.

Ibarra-Drendall C, Troch MM, Barry WT, Broadwater G, Petricoin EF 3rd, Wulfkuhle J, Liotta LA, Lem S, Baker JC Jr, Ford AC, Wilke LG, Zalles C, Kuderer NM, Hoffman AW, Shivraj M, Mehta P, Williams J, Tolbert N, Lee LW, Pilie PG, Yu D, Seewaldt VL. Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways [Internet]. Breast Cancer Res Treat 2011 Jun; Available from:

Improta G, Zupa A, Fillmore H, Deng J, Aieta M, Musto P, Liotta LA, Broaddus W, Petricoin EF 3rd, Wulfkuhle JD. Protein pathway activation mapping of brain metastasis from lung and breast cancers reveals organ type specific drug target activation. J. Proteome Res 2011 Jul;10(7):3089-3097.

Dey-Guha I, Wolfer A, Yeh AC, G Albeck J, Darp R, Leon E, Wulfkuhle J, Petricoin EF 3rd, Wittner BS, Ramaswamy S. Asymmetric cancer cell division regulated by AKT. Proc. Natl. Acad. Sci. U.S.A 2011 Aug;108(31):12845-12850.

Schrag M, Mueller C, Oyoyo U, Smith MA, Kirsch WM. Iron, zinc and copper in the Alzheimer’s disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion. Prog. Neurobiol. 2011 Aug;94(3):296–306.

Gioeli D, Wunderlich W, Sebolt-Leopold J, Bekiranov S, Wulfkuhle JD, Petricoin EF 3rd, Conaway M, Weber MJ. Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer [Internet]. Mol Cancer Ther 2011 Aug; Available from:

Xia W, Liu Z, Zong R, Liu L, Zhao S, Bacus SS, Mao Y, He J, Wulfkuhle JD, Petricoin EF 3rd, Osada T, Yang X-Y, Hartman ZC, Clay TM, Blackwell KL, Lyerly HK, Spector NL. Truncated ErbB2 Expressed in Tumor Cell Nuclei Contributes to Acquired Therapeutic Resistance to ErbB2 Kinase Inhibitors. Mol. Cancer Ther 2011 Aug;10(8):1367-1374.

Mueller C, Edmiston KH, Carpenter C, Gaffney E, Ryan C, Ward R, White S, Memeo L, Colarossi C, Petricoin EF 3rd, Liotta LA, Espina V. One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens. PLoS ONE 2011;6(8):e23780.

Goudarzi M, Ross MM, Zhou W, Van Meter A, Deng J, Martin LM, Martin C, Liotta L, Petricoin E, Ad N. Development of a novel proteomic approach for mitochondrial proteomics from cardiac tissue from patients with atrial fibrillation. J. Proteome Res 2011 Aug;10(8):3484-3492.

Liotta LA, Petricoin E. Cancer biomarkers: closer to delivering on their promise. Cancer Cell 2011 Sep;20(3):279-280.

Tsang A, Seidle H, Jawaid S, Zhou W, Smith C, Couch RD. Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. PLoS ONE 2011;6(6):e20884.

Zhou W, Capello M, Fredolini C, Racanicchi L, Piemonti L, Liotta LA, Novelli F, Petricoin EF. Proteomic analysis reveals Warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells [Internet]. Journal of Proteome Research 2011 Nov; Available from:

Bose D, Zimmerman LJ, Pierobon M, Petricoin E, Tozzi F, Parikh A, Fan F, Dallas N, Xia L, Gaur P, Samuel S, Liebler DC, Ellis LM. Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells. Br. J. Cancer 2011 Nov;105(11):1759–1767.

Lu WJ, Zhou W, Kreutz Y, Flockhart DA. Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series. J Med Case Reports 2011;5:513.

Tamburro D, Fredolini C, Espina V, Douglas TA, Ranganathan A, Ilag L, Zhou W, Russo P, Espina BH, Muto G, Petricoin EF, Liotta LA, Luchini A. Multifunctional Core-Shell Nanoparticles: Discovery of Previously Invisible Biomarkers [Internet]. Journal of the American Chemical Society 2011 Nov. Available from:

Zhou W, Capello M, Fredolini C, Racanicchi L, Piemonti L, Liotta LA, Novelli F, Petricoin EF. Phosphoproteomic Analysis of Pancreatic Ductal Adenocarcinoma Cells Reveals Differential Phosphorylation of Cell Adhesion, Cell Junction and Structural Proteins [Internet]. Journal of Proteomics & Bioinformatics 2011;04 Available from: